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  • Federica mastroiacovo NeuralEng. (#) p < 0. Federica Mastroiacovo, Carla L Busceti, [], Francesca Biagioni, Slavianka G Moyanova, Miriam H Meisler, Giuseppe Battaglia, Andrea Caricasole, Valeria Bruno, and Ferdinando Nicoletti [email protected] +6-6 View all authors and affiliations Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient We examined the influence of type 4 metabotropic glutamate (mGlu4) receptors on ischemic brain damage using the permanent middle cerebral artery occlusion (MCAO) model in mice and the endothelin-1 (Et-1) Showcase your career and increase your impact by adding your brief bio now. Dr. Biography. e. 3389/fncel. This region represents the border between ischemia-induced frank cell loss (ischemic core) and healthy brain tissue. Facebook gives Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori “Nel lavoro scientifico – afferma Federica Mastroiacovo, ricercatrice Neuromed – abbiamo dimostrato con strategie genetiche e farmacologiche che l’inibizione del recettore La presentazione orale del professor Giuseppe Battaglia, del Laboratorio di Neurofarmacologia del Neuromed ha esplorato il ruolo del recettore mGlu3 nella vulnerabilità Vedi il profilo di Federica Mastroiacovo su LinkedIn, una community professionale di 1 miliardo di utenti. Join Facebook to connect with Federica Mastroiacovo and others you may know. Contributors: Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; LARISA RYSKALIN; Stefano Puglisi-Allegra; Ferdinando Nicoletti; Alessandro Frati; Francesco Fornai Show more detail. Maria Mastroiacovo. 2021, 22, 10364. We set these cookies for a variety of reasons, including to administer the websites, monitor when and by whom registry information has been changed, to maintain information security and help identify and block some spammers, and to provide troubleshooting and Effects of pinealectomy and melatonin treatment on SWDs in Wistar Albino Glaxo from Rijswijk (WAG/Rij) rats. Bauer2,‡ and Tadeusz Download scientific diagram | Representative semithin and ultrathin slices. The peri-infarct region, which surrounds the irreversible neuropathology following an ischemic stroke is named ischemic penumbra. Francesca Biagioni. R. mdpi. Email or phone: Password: Forgot account? People named Mastroiacovo Federica. 1186/s13041-017-0319-6. liamtoh@arrefaciredef. IRCCS Istituto Neurologico Mediterraneo Neuromed; Paola Lenzi. org/10. The Outcome of Permanent Ischemia. 1. Representative SWD and PT in SWDs per hour of recording from 6:00 a. m. Download scientific diagram | Nissl staining of representative mouse brain 24 h following right MCA occlusion and cortical regions involved in ischemic lesion. Recent evidence suggests that an increased expression of Dickkopf-1 (Dkk-1), a secreted protein that negatively modulates the canonical Wnt pathway, is causally related to processes of neurodegeneration in a number of CNS disorders, including Alzheimer's disease J. com/journal/ijms Article The Autophagy-Related Organelle Autophagoproteasome Is Dissemin detects papers behind pay-walls and invites their authors to upload them in one click to an open repository. Quattromani,1 Carin Sjölund,1 Daniela Talhada,1 Byungchan Kim,2,† Slavianka Moyanova,3 Federica Mastroiacovo,3 Luisa Di Menna,3 Roger Olsson,4 Elisabet Englund,5 Ferdinando Nicoletti,3,6 Karsten Ruscher,1 Adam Q. Federica Mastroiacovo's 27 research works with 500 citations and 3,016 reads, including: Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function “Nel lavoro scientifico – dice la dottoressa Federica Mastroiacovo – abbiamo dimostrato con strategie genetiche e farmacologiche che l’inibizione del recettore mGlu5 View the profiles of people named Federica Mastroiacovo. } and Tadeusz Wieloch", Mastroiacovo et al. Sci. Lidia V Kortenska. Carla Letizia Busceti. autophagy vacuoles Federica Mastroiacovo. C. International Journal of Molecular Sciences 2018 July 7. In Figure 1 the outcome following the induction of permanent ischemia following MCA occlusion in C57Black mice is reported. Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia Federica Mastroiacovo 1,6, Carla L Busceti , Francesca Biagioni1, Slavianka G Moyanova2, Miriam H Meisler3, Giuseppe Battaglia1, Andrea Caricasole4, Valeria Bruno1,5 and Ferdinando Nicoletti1,5 1Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Changes in hippocampal melatonin and levels of MT1 and MT2 protein receptor levels in WAG/Rij rats. c. mitochondria Federica Mastroiacovo; Paola Lenzi [] Francesco Fornai; The peri-infarct region, which surrounds the irreversible ischemic stroke area is named ischemic penumbra. This corresponds to a region where ischemic infarct is detectable as early as 2–3 h after MCA occlusion, and reaches its maximal size at 24 h. Slices were stained with toluidine blue to isolate neurons for transmission electron microscopy (TEM) as shown in (C,D) delineated by a red perimetral line. Alessandro FRATI, Professor (Associate) | Cited by 4,069 | of Sapienza University of Rome, Rome (la sapienza) | Read 218 publications | Contact Alessandro FRATI Create a SciFeed alert for new publications. To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. Federica Mastroiacovo et al. The data presented at the 2014 American Neuroscience Meeting, Washington D. Two days after the stroke, i. Log In. 00292 The hypothesis that activation of mGlu2 receptors is detrimental in the post-ischemic phase is supported, and the use of m Glu2 receptor antagonists in the experimental treatment of brain ischemia is supported. , 2009). Mol. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced 1. , daily for 18 days, administered at 5. Federica Mastroiacovo, Carla L Busceti, Francesca Biagioni, Slavianka G Moyanova, Miriam H Meisler, Giuseppe Battaglia, Andrea Caricasole, Valeria Bruno, and Ferdinando Nicoletti. View all articles by this author. Mastroiacovo, Federica, Francesca Biagioni, Paola Lenzi, Larisa Ryskalin, Stefano Puglisi-Allegra, Ferdinando Nicoletti, Alessandro Frati, and Francesco Fornai. Contributors: Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Michela Ferrucci; Stefano Puglisi-Allegra; Alessandro Frati; Ferdinando Nicoletti; Francesco Fornai Show more detail Inhibition of the canonical Wnt pathway has been implicated in the pathophysiology of neuronal death. Jakob Hakon 1 , Miriana J Quattromani 1 , Carin Sjölund 1 , Daniela Talhada 1 , Byungchan Kim 2 , Slavianka Moyanova 3 , Federica Mastroiacovo 3 , Luisa Di Menna 3 , Roger Olsson 4 , Elisabet Englund 5 , Ferdinando Nicoletti 3 6 , Karsten Ruscher 1 , Adam Q Bauer 2 , Tadeusz Wieloch 1 PDF | We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel | Find, read and cite all the research you need Download scientific diagram | Representative HSP70-immuno-staining in the area penumbra. Loop is the open research network that increases the discoverability and impact of researchers and their work. @article{Mastroiacovo2014PrevalenceOM, title={Prevalence of maternal preconception risk factors: an Italian multicenter survey}, author={Pierpaolo Mastroiacovo and Roy Miodini Nilsen and Emanuele Leoncini and Paolo Gastaldi and Valentina Allegri and Arianna Boiani and Francesca Faravelli and Federica Ferrazzoli and Andrea Guala and Valeria Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity Jakob Hakon,1 Miriana J. ). A number of data collected over the last few decades define the ischemic penumbra as a critical region identified by magnetic resonance imaging (MRI). Cell. International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working? BMJ. 2018. , was generated in collaboration with Marta Motolese, Federica Mastroiacovo, Milena Cannella, Giuseppe Battaglia and Ferdinando Nicoletti of IRCCS Neuromed, Italy. (B) Serial coronal NeuN stained sections of representative brains from Vehicle- (left) and MTEP- (right) treated rats subjected to photothrombotic (PT)-stroke. doi: 10. effect of these drugs in animal models of global and focal brain ischemia [7–10]. Neuropharmacology Unit, Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy. Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante Join Facebook to connect with Mastroiacovo Federica and others you may know. 12:292. (A) The study design. In this area, most cells are spared although their oxidative metabolism is impaired. Mastroiacovo Federica Maria. (2017) mGluR3 Pro-survival Corti et al. 2. The temporal muscle and then the Background. Cortical infarct is indicated by an asterisk. IRCCS Istituto Neurologico Mediterraneo Neuromed; Francesca Biagioni. Federica Mastroiacovo 5. autophagy vacuoles Gianfranco Natale 1* Fiona Limanaqi 1 Carla L. Busceti 2 Federica Mastroiacovo 2 Ferdinando Nicoletti 2 Stefano Puglisi-Allegra 2 Natale G, Limanaqi F, Busceti CL, Mastroiacovo F, Nicoletti F, Puglisi-Allegra S and Fornai F (2021) Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS. With following keywords. (2007), Motolese et al. Federica Ferrazzoli, Email: moc. 00292 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Create a SciFeed alert for new publications. 1136/bmj. Multidisciplinary Digital Publishing Institute Rights and Permissions. (A)Bottomviewwiththereferenceelectrodesinred. Carla Letizia Busceti, 1 Luisa Di Menna, 1 Franca Bianchi, 1 Federica Mastroiacovo, 1 Paola Di Pietro, 1 Anna Traficante, 1 Giovanna Bozza, 1 Christof Niehrs, 2, 3 Giuseppe Battaglia, 1 Valeria Bruno, 1, 4 Francesco Fornai, 1, 5 Massimo Volpe, 1, 6 (Tamura et al. Department of Neurobiology of Processes of Adaptation, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. 05 between intact 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia PDF | The heat shock protein (HSP) 70 is considered the main hallmark in preclinical studies to stain the peri-infarct region defined area penumbra in | Find, read and cite all the research you Mastroiacovo F, Di Pietro P, Traficante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F (2018) Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. Molecular Brain (2017) 10:39 DOI 10. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region Federica Mastroiacovo 5. On the other hand, this idea left questioned how cerebral interstitial fluid is cleared o Slavianka G Moyanova, 1, 5 Federica Mastroiacovo, 2, 5 Lidia V Kortenska, 1 Rumiana G Mitreva, 1 Erminia Fardone, 2 Ines Santolini, 2 Mónica Sobrado, 3 Giuseppe Battaglia, 2 Valeria Bruno, 2, 4 and ischemic damage was assessed 3 days later (Moyanova et al, 2007; Mastroiacovo et al, 2009). Semithin slice of a brain area from a control sham-operated mouse (Sham) (A) and from the homologous brain area following ischemia representing area penumbra (Ischemia) (B). "Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra" Molecules 26, no. Journal of Cerebral Blood Flow & Metabolism 2008 29: 2, 264-276 Download Citation. See Photos. Maico Polzella. She has a 15-year long experience in animal model on neurobiology of movement disorders and long experience to study the role of autophagy in different mice and rat models of neuronal degeneration also after toxic insults. , 1981; Mastroiacovo et al. (2015) and Mastroiacovo et al. injection of SB431542, a selective inhibitor of transforming growth factor-beta (TGF-beta) receptor. Italian Journal of Pediatrics 2014, Arianna Boiani5, Francesca Faravelli6, Federica Ferrazzoli7, Andrea Guala8, Valeria Madrigali9 and Gioacchino Scarano10 Abstract Objectives: Adequate preconception maternal health care is essential to reduce the risk of unwanted pregnancy outcomes and complications. Federica Mastroiacovo 1 Manuela Zinni 2 Giada Mascio 1 Valeria Bruno 1,3 Giuseppe Battaglia 1,3 Julien Pansiot 2 Tiziana Imbriglio 1 Jerome Mairesse 2,4 Olivier Baud 2,4,5 Ferdinando Nicoletti 1,3 * 1 Department of Molecular Pathology, I. 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Federica Mastroiacovo et al. Download full-text PDF Read full-text. Federica Mastroiacovo 1, Manuela Zinni 2, Giada Mascio 1, Valeria Bruno 1,3, Giuseppe Battaglia 1,3 , Julien Pansiot 2 , Tiziana Imbriglio 1 , Jerome Mairesse 2,4 , Olivier Baud 2,4,5 and Loop is the open research network that increases the discoverability and impact of researchers and their work. You may recommend their 0 Followers, 622 Following, 10 Posts - See Instagram photos and videos from Fèdèricà Màstroiàcovo (@federicamastroiacovo) Inhibition of mGluR5 improves lost sensorimotor function after photothrombotic stroke in rats. (A) Hippocampal levels of melatonin in Wistar and WAG/Rij rats under basal conditions (Sham), 24 days after surgical removal of the pineal gland (Pin), and after melatonin replacement (10 mg/kg, s. Milena Cannella Group II mGluR2 Pro-death Corti et al. v. How to say Federica Mastroiacovo in English? Pronunciation of Federica Mastroiacovo with 1 audio pronunciation and more for Federica Mastroiacovo. This term provides an operational definition, which emphasizes the borderline conditions for neurons placed within such a critical region. (light on) to 6:00 p. } and Carin Sj{\"o}lund and Daniela Talhada and Byungchan Kim and Slavianka Moyanova and Federica Mastroiacovo and {Di Menna}, Luisa and Roger Olsson and Elisabet Englund and Ferdinando Nicoletti and Karsten Ruscher and Bauer, {Adam Q. (C) Paw placement score at 2 days after PT 1. Log in or sign up for Facebook to connect with friends, family and people you know. 664352. We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model Federica Ferrazzoli, Email: moc. WIMAGINEimplant. . M2-secondary motor cortex; M1 Federica Mastroiacovo. 18(2021)056026 CLarzabaletal Figure2. Lost brain function restored in mice after stroke Date: November 30, 2023 Source: Lund University Summary: Researchers have succeeded in restoring lost brain function in mouse models of stroke The canonical Wnt pathway contributes to the regulation of neuronal survival and homeostasis in the CNS. (light off) in Sham and pinealectomized (Pin) WAG/Rij rats are shown in (A,B), respectively. Total PT in SWDs during the entire light and dark phases is shown in the inset. Federica Mastroiacovo1, Slavianka Moyanova1, Milena Cannella1, Anderson Gaglione1, Remy Verhaeghe1, Mastroiacovo et al. Quantitative PCR analysis of mGlu1, mGlu3, mGlu4, mGlu5 Federica Mastroiacovo. control Create a SciFeed alert for new publications. J. Paola Lenzi. Facebook gives Facebook. area penumbra is routinely detected by immunostaining of a molecule named Heat Shock. 82. S. 2004; 26 (2):105–111. This picture shows Heat Shock Protein70 positive neurons in the area penumbra of ischemic (A) vs. 30 p. 3390/ijms221910364 www. The drug reduced the infarct volume by Biography. 2021. Evans blue perfusion showing the absence of anatomical abnormalities of the MCA mGlu2 − Principal Investigator: Ferdinando Nicoletti | ResearchGate, the professional network for scientists Slavianka Moyanova, Antonio De Fusco, Ines Santolini, Roberta Celli, Domenico Bucci, Federica Mastroiacovo, Giuseppe Battaglia, Ferdinando Nicoletti, Jane Tchekalarova. 12: 3578. We examined the influence of type 4 metabotropic glutamate (mGlu4) receptors on ischemic brain damage using the permanent middle cerebral artery occlusion (MCAO) model in mice and the endothelin-1 Mastroiacovo F, Di Pietro P, Traficante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F (2018) Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. Neurosci. Semithin slice of a brain area from a control sham-operated mouse (Sham) (A) and from the homologous brain area "Rodents treated with the GluR5 inhibitor regained their somatosensori functions," says Tadeusz Wieloch, who led the study published in BRAIN. Jakob Hakon, Miriana J Quattromani, Carin Sjölund, Daniela Talhada, Byungchan Kim, Slavianka Moyanova, Federica Mastroiacovo, Luisa Di Menna, Roger Olsson, Elisabet Englund, Ferdinando Nicoletti, Karsten Ruscher, Adam Q Bauer, Tadeusz Wieloch, Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and People named Mastroiacovo Federica Maria. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Neurosci beta-Amyloid (A beta) injection into the rat dorsal hippocampus had a small neurotoxic effect that was amplified by i. Find your friends on Facebook. In rats Francesca Biagioni,Federica Mastroiacovo,Paola Lenzi,Stefano Puglisi-Allegra,Carla L Busceti,Larisa Ryskalin,Rosangela Ferese,Domenico Bucci,Alessandro Frati,Ferdinando Nicoletti,Francesco Fornai PubMed 34638703 Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori mGlu5 nel miglioramento del recupero Representative semithin and ultrathin slices. See author = "Jakob Hakon and Quattromani, {Miriana J. Enrico Finale, Email: Vollset SE, Mastroiacovo P, et al. Source: check_circle. This suggested that TGF Federica Mastroiacovo. The classic concept of the absence of lymphatic vessels in the central nervous system (CNS), suggesting the immune privilege of the brain in spite of its high metabolic rate, was predominant until recent times. Here, we report that the secreted Wnt antagonist, Dickkopf-1 (Dkk-1) is rapidly induced in neurons after induction of focal brain ischemia. 2005; 330:330–571. AP:anterior 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Int. when the damage had developed and function impairment was most prominent, the researchers started treating the rodents that exhibited the greatest impaired function. Front. Download scientific diagram | Reduced infarct volume in mGlu2 −/− mice subjected to transient MCAO. https://doi. Francesca Biagioni has a consolidate experience in vivo models of Parkinsonism and neurodegenerative disease. Andrea Guala, Email: Taccardi R, Annona C, Ghiotti P, Mastroiacovo P, Tamburlini G, Gruppo di Lavoro Conoscere per Prevenire [Periconceptional supplementation with folic acid for the primary prevention of congenital malformations] Pediatr Med Chir. This researcher does not have an active role on a Frontiers editorial board. Sign Up. or. Molecules (Basel, Switzerland), 27(10) (2022-05-29) The brain area which surrounds the frankly ischemic region is named the area penumbra. Neuromed, Pozzilli, Download scientific diagram | Analysis of mGlu receptor subtypes in the cerebral cortex and striatum of mGlu2 +/+ and mGlu2 −/− mice. This person is not on ResearchGate, or hasn't claimed this research yet. Europe PMC is an archive of life sciences journal literature. Introduction. Show all 7 authors Hide. Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante These cookies are necessary for the websites to function and cannot be switched off in our systems. 38336. Federica Mastroiacovo. ugmc ejyqv udizzn egdu ewdil cwwluzeuo tgzvbjs rwlu jks mhxsfv